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Carnitine is a vitamin like nutrient and occurs naturally
in the body. It is essential for the fat metabolism.
Not without good reason it is named "the energy
vitamin".Carnitine is an amino acid which, has
been found to have a wide range of protective effects
and health benefits as long as it is consumed in sufficient
amounts. Carnitine's protective effects are associated
primarily with heart health. It has been shown to be
a factor in the protection against heart disease.
One of a number of additional health benefits of carnitine
is that it increases fat metabolism. It therefore helps
in avoiding obesity, so the claim goes. Obviously, if
carnintine can aide in avoiding obesity, it automatically
qualifies as a medication against many health problems,
which are associated with being overweight.
Carnitine is popular among athletes and body builders
as it increases stamina and has been shown to help in
developing muscle mass.
We haven't encountered claims that carnitine would
be helpful in sexual functions, even though such claims
(usually unsubstantiated) are regularly made for any
kind of nutritional product as they tend to increase
sales.
1905 L-Carnitine
was first found in muscle extracts by Gulewitch and
Krimberg and was so named from the Latin caro, carnis
(meaning flesh or meat).
1927 The chemical structure of L-Carnitine
was confirmed.
1947 Fraenkel conducted research for
as yet undiscovered B-vitamins.
1952 Fraenkel worked on nutritional
requirements of mealworms (Tenebrio molitor) and found
they require L-Carnitine as an essential growth factor
in addition to folic acid and the other known B vitamins.
1958 Fritz found that L-Carnitine increased
the rate at which cells (mitochondria) burned fat. This
established L-Carnitine's fundamental role in fat oxidation.
1970 Intensive research on the functions
of L-Carnitine.
1980 L-Carnitine became commercially
available.
1993 Generally Recognized As Safe (GRAS)
- an independent expert committee of scientists evaluated
the GRAS status of L-Carnitine as a dietary supplement.
They concluded that L-Carnitine and its freely ionizable
salts such as L-Carnitine L-Tartrate and L-Carnitine
Magnesium Citrate can be safely ingested by adults at
20 mg/kg/day (1200 mg for a 60 kg person) for a broad
range of uses.
Fatty acid oxidation:
Fatty acids are one of the primary energy sources for
the body. oxidation is the process by which fatty acids
are broken down for the ultimate production of energy.
Although fatty acids need to enter the mitochondria
for oxidation, they are unable to penetrate the inner
mitochondrial membrane. L-Carnitine is essential to
transport long chain fatty acids across the mitochondrial
membrane for subsequent fat breakdown and energy production.
Free Co-Enzyme A (CoA) buffer:
L-Carnitine has been shown to buffer the bound CoA
to free CoA ratio and removes toxic concentrations of
acyl-CoA thereby helping to ensure that energy production
can continue.
Detoxification:
Another important function of L-Carnitine is the ability
to shuttle short chain fatty acids from inside the mitochondria
to the cytosol.
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